IBS Research
posted on April 22nd, 2009 - Filed in Uncategorized - 2 comments »I had no idea Irritable Bowel Syndrome was so prolific. One in ten Calgarians are suffering from this disorder. But thankfully there is research underway at the U of C that could help. And it might only be 5 to 10 years away.
Here’s the story.
Katharine Mccombe has lived with irritable bowel syndrome for 18 years. It leaves her unable to work, unable to eat during the day, and in an incredible amount of pain.
“The pain is beyond anything -beyond any other symptoms – it’s absolutely excruciating.”
And those symptoms are embarassing. Mccombe says they make her socially unacceptable.
“It’s not appropriate for an adult not to be able to make it to the washroom on time, or not be able to control their gas.”
But research underway at the University of Calgary could one day help people like Mccombe. Doctor Keith Sharkey is looking into molecules called “endogenous cannabinoids.”
“These are chemically similar to cannabis, but they act on the same receptor as the cannabis plant in your body.”
And historically cannabis has been very effective in treating gastrointestinal problems.
Doctor Sharkey says “we know the cannabis plant has been used medicinally for centuries and one of the things it’s used for medically are GI disorders.”
Doctor Sharkey and his team are working on 3 or 4 approaches with these cannabinoids that could help people with IBS.
Sharkey says,”endogenous cannabinoids appear to play a role in moderating inflammation in the gut and we know inflammation is associated with IBS and other bowel disorders.”
What’s most promising about this research is these cannabinoids are made by the body itself – so there are likely to be few side effects.
“Endogenous cannabinoids are safe because they’re made by our bodies and if we can find a way of harnessing them for example harnessing their action, it’s unlikely to have any side effects and maybe some benefits.”
And that’s exactly what Mccombe is hoping for. Some kind of medication that would actually work so she could get her life back.
“It would be absolutely fantastic, and I always have hope but to be honest I can’t imagine it.”
For more information on IBS and other gastrointestinal problems visit the website:



